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In Vivo RNAi


RiboBio genOFF in vivo siRNAs are chemically modified duplexes intended to use in in vivo experiments based on its advanced stability, less toxicity, higher efficiency and easier utility. The new design technologies ensure genOFFin vivo siRNAs are capable of being constant in serum more than 48 hours, which allows its application in RNAi based drug development, in vivo drug target validation and in vivo gene function investigations.

Optimized design algorithm minimizes off-target effects

Chemically modifications improve stability 

Proper conjugates for easily infiltrating into cells
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