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Exon-intron circular RNAs regulate transcription in the nucleus

发布日期:2015/2/28 14:46:39

期刊名称:nature structural & molecular biology

期刊号:doi:10.1038/nsmb.2959

通迅作者:单革

作者单位:中国科技大学生命科学学院

使用产品与服务:antisense oligonucleotides

文章摘要:Noncoding RNAs (ncRNAs) have numerous roles in development and disease, and one of the prominent roles is to regulate gene expression. A vast number of circular RNAs (circRNAs) have been identified, and some have been shown to function as microRNA sponges in animal cells. Here, we report a class of circRNAs associated with RNA polymerase II in human cells. In these circRNAs, exons are circularized with introns‘retained’between exons; we term them exon-intron circRNAs or EIciRNAs. EIciRNAs predominantly localize in the nucleus, interact with U1 snRNP and promote transcription of their parental genes. Our findings reveal a new role for circRNAs in regulating gene expression in the nucleus, in which EIciRNAs enhance the expression of their parental genes in cis, and highlight a regulatory strategy for transcriptional control via specific RNA-RNA interaction between U1 snRNA and EIciRNAs.

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